These two teams experienced vastly contrasting fortunes in their respective opening games of the competition. Ecuador suffered a chastening 4-0 loss against Uruguay, while Chile defeated Japan by the same scoreline.
Chile are chalked up as SportPesa's 4/5 (1.80) favourites to come out on top. Ecuador are available at 7/2 (4.50) to bag a vital victory. SportPesa go 51/20 (3.55) that these two teams settle for a share of the spoils.
Just one of the last 12 matches between these nations has ended all square.
Reinaldo Rueda's men are heavily reliant on a host of vastly experienced stars. Manchester United's Alexis Sanchez and Barcelona midfielder, Arturo Vidal are both expected to start for the defending champions. Mexican-based striker, Eduardo Rojas, will be in confident mood after scoring twice against Japan.
Antonio and Enner Valencia are, perhaps, Ecuador's most recognisable stars. The brothers are both expected to start for Hernan Gomez's men. Jose Quintero is suspended after being sent off against Uruguay last time out.
Chile have been beaten in just one of their last 13 matches in this competition. Rueda's side opened their successful 2015 campaign with a 2-0 win against Ecuador. SportPesa offer 13/2 (7.50) that the defending champions again win 2-0 on this occasion. Chile (-1) can be backed at 2/1 (3.0) with the same firm to beat the handicap mark.
There have been at least three goals scored in five of the last six matches between these two nations. SportPesa offer even money (2.0) that there are at least three goals scored this weekend. The same firm go 10/11 (1.91) that both teams are on target in Salvador.
Chile will be confident that they can further extend their impressive Copa America record. Rueda's men failed to qualify for the World Cup 12 months ago, but always seem to find their most impressive form in this competition. By contrast, Gomez's side are out-of-sorts.
Ecuador have won just two of their last nine matches and are under tremendous pressure to take something from this game. Indeed, defeat could well see the underdog's Copa America campaign effectively ended.
Furthermore, Gomez's side have won just two of their last 17 fixtures in this competition.
The defending champions, then, look well-placed to chalk up a comfortable victory when these rivals lock horns in Salvador. As such, SportPesa's generous 2/1 (3.0) quote for Chile (-1) to see off Ecuador could well represent real value for punters here.