The five-time Ballon d'Or winner has already found the net on five occasions since arriving in Turin and boasts an incredible 120 goals in this competition - more than anyone else in history. He's 6/1 (7.0) to fire his new club to an elusive title.
bet365 go 21/20 (2.05) that Ronaldo scores a first European goal for his new side against his former employers at Old Trafford and 10/3 (4.33) that the Portugal international breaks the deadlock with the opening strike.
Having left Manchester for Real Madrid back in 2009, Ronaldo has found the net in both previous meetings with United in this competition.
Due to their stuttering start to the season and the visitors' impressive form, the bookmakers have United priced as underdogs for the game. bet365 offer 21/10 (3.10) about a home win while the visitors are an industry-best quote of 6/4 (2.50) to secure three points. The same firm are also best priced on the draw at 23/10 (3.30) at the time of writing.
Given his scoring record in the Champions League, backing Ronaldo to net multiple times against United could prove popular.
As well as betting on goals, bet365 now offer wagers on various stat-based markets. These options include both individual and team total tallies on metrics such as shots, shots on target and tackles.
Ronaldo has scored five goals and provided two assists in six Champions League games against his former clubs.
It's 2/1 (3.0) that he assists a teammate in this match, that’s something that has already happened four times in Serie A this season, so it could be an interesting betting proposition for those seeking a bigger price.
The summer signing was sent off in his first Champions League appearance for the Old Lady, a ban that was reduced on appeal which allows him to take part in Tuesday's clash.