Having defeated West Bromwich Albion in their last English Premier League clash, Pep Guardiola's side will look to continue their impressive form which has seen them win 13 matches in a row in all competitions - a record that helps them sit atop the league standings, five points clear of their closest rival - Manchester United.
In addition, the Citizens are unbeaten in 21 competitive games. Knowing that a victory will see them qualify for the knock-out stage of the competition, they will hope to get the win in Campania which Bet365 offers at (2.50).
(3.60) is qouted by the same firm for the game to end all square.
For the Italian side, they will hope to do better than their last meeting with their opponents where they lost 2-1 at the Etihad Stadium.
Though they boast of a striking record in the Serie A, winning ten of their 11 matches played thus far which sees them top the league standings with 31 points, they have not been consistent in the Champions League hitherto losing two games out of three.
They occupy third spot in the group with three points and will have to be solid in defence and sharp in attack in order to boost their chances of qualifying for the next stage. Odds of (2.60) are available for Partenopei to upset their visitors.
Both sides have been clinical in front of goal with City ammasing 43 goals in just 14 games while their hosts boast of 36 goals in the same number of matches. Bookies offer (1.44) for more than three goals in Naples and (1.40) for both sides to score.
Manchester City conceded two goals in their last outing against West Brom while Napoli have let in goals in three of their last four duels. Bet365 Betis tipping Maurizio Sarri's men at (1.16) not to keep a clean slate while their rivals are also ( 1.18) to concede.