Rui Vitoria's team managed just one goal and failed to pick up a single point during the group stages of this competition last term and their opening assignment this time around could barely be tougher.
The German giants are in fantastic form under the stewardship of new manager Niko Kovac, who has overseen seven consecutive competitive victories since taking up the reins from Jupp Heynckes in the summer.
Given the apparent gulf in pedigree between these teams, it is unsurprising that the visitors are as short as 8/15 (1.53) with bet365 to kick off their campaign with a win, while Benfica can be backed at 11/2 (6.50) to claim a famous victory.
The odds compilers offer 7/2 (4.50) that this Group E fixture results in both sides settling for a share of the spoils.
Corentin Tolisso suffered a serious knee injury against Bayer Leverkusen at the weekend and is out, meaning James Rodriguez should come into the side.
Eduardo Salvio has scored four goals in his last three matches for Benfica and will surely be brimming with belief ahead of this clash.
In seven competitive matches this season, Bayern have hit a huge 23 goals and scored at least three times in each of their last four fixtures.
The visitors could prove to be too hot to handle for Vitoria's team in Lisbon and bet365 offer a tempting 6/4 (2.50) that Bayern score more than two goals in this game, and 11/10 (2.10) that Bayern win a match featuring three or more goals.
Better value may lie in backing the Bundesliga side claiming a comfortable victory and it is the 6/5 (2.20) quote from bet365 for Bayern (-1) to beat the handicap mark that may represent best value for punters ahead of Wednesday's Champions League crunch.
Odds correct at time of writing. Please gamble responsibly.