Ernesto Valverde's men suffered a shock 2-0 defeat at Granada at the weekend and find themselves four points off the leaders following one of their poorest starts to a season in recent memory.
Villarreal for their part have recorded back to back wins in La Liga and head to Catalonia on the same number of points as Barca.
While they have struggled on the road this season, the champions remain strong at home where they have won both of their games by a 5-2 scoreline.
Barcelona vs Villarreal Team News
Lionel Messi got his first La Liga minutes of the season at the weekend against Granada, and it remains to be seen whether he is fit enough to start in midweek.
Ousmane Dembele and Samuel Umtiti are still sidelined for the Blaugrana with injury.
Villarreal are without injured full-back Alberto Moreno.
Barcelona vs Villarreal Preview
These sides are the two top-scoring outfits in the Spanish top flight, with both having netted 12 times in five games.
Barcelona meanwhile have failed to keep a clean sheet in any of their five domestic games this term - which is an eye-catching statistic for the champions at the start of the season.
The Yellow Submarine have enjoyed successive shutouts in their wins against Leganes and Valladolid but there remains question-marks about their defence when faced with quality attacking opposition.
Villarreal have scored in five of their last seven visits to the Camp Nou in all competitions and they are likely to do so once more, while Barca have hit the back of the net in their last 29 home matches in La Liga meaning goals at both ends look almost guaranteed.
Tips and predictions
Both teams to score and over 2.5 goals is offered at 1.70 with this selection paying out in five of the last seven meetings between these teams in Catalonia.
Odds correct at the time of publish. Please gamble responsibly. Check out the latest football odds at Sportsbet.