Matchday one saw Ernesto Valverde's men claim a goalless draw at Borussia Dortmund thanks in large part to an excellent showing from their goalkeeper Marc-Andre Ter Stegen.
Inter for their part were held at home to 1-1 stalemate by Slavia Prague in one of the shocks of the round.
Inter have made a 100 per cent start to their Serie A campaign winning all six of their matches to sit top the table.
Barcelona vs Inter Milan Team News
Lionel Messi missed the weekend's win at Getafe, but the club are hopeful that he could be fit enough to feature at some point against Inter.
Ousmane Dembele could also play, although teenage winger Ansu Fati missed the trip to the capital and is a doubt.
Defenders Samuel Umtiti and Jordi Alba could also miss out.
The visitors meanwhile will be without striker Romelu Lukaku for their trip to Catalonia.
Barcelona vs Inter Milan Preview
The Blaugrana are unbeaten in their last 23 home matches in all competitions of which they have won 20, while their European record is even more impressive.
Bayern Munich were the last European team to win at Camp Nou over six years ago and in the subsequent 32 matches Barca have won 29 and drawn three.
One of those victories was against Inter 12 months ago, while the Nerazzuri also lost at Spurs in the group stages last season.
Antonio Conte's side may have started the current season strongly, but it is extremely difficult to back anything other than a home win when Barca are in Champions League action at Camp Nou.
Tips and predictions
Barcelona to win and over 1.5 goals in the game is priced at 1.72 and this bet has paid out in 27 of Barcelona's last 32 home games in the Champions League.
Odds correct at the time of publish. Please gamble responsibly. Check out the latest football odds at Sportsbet.