The Catalan outfit are currently 11 points clear of second-placed Atletico Madrid, who play earlier in the day, and depending on results can move further clear.
They come into the game on a high, having booked their place in the semi-final of the Copa del Rey on Thursday, with new signing Philippe Coutinho making his first appearance.
Alaves, meanwhile, are struggling at the other end of the table and have lost their last three games in all competitions.
|Game||Barcelona vs Alaves|
|Date||Sunday, January 28|
|Time||19:45 GMT / 14:45 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV CHANNEL & LIVE STREAM
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial) .
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
In the United Kingdom (UK) the game is available to watch live on television on Sky Sports Football and can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sly Sports Football||Sky Go|
SQUADS & TEAM NEWS
|Goalkeepers||Ter Stegen, Cillessen|
|Defenders||Semedo, Pique, Alba, Digne, Mina, VIdal, Umtiti|
|Midfielders||Rakitic, Busquets, Iniesta, Coutinho, Paulinho, Roberto|
|Forwards||L. Suarez, Messi, Alcacer|
Barcelona are without their record signing Ousmane Dembele, while Thomas Vermaelen is also out of contention. Andre Gomes is suffering digestive problems, while Denis Suarez and Gerard Deulofeu have been left out of the panel.
Philippe Coutinho made his first appearance for the club from the bench on Thursday and could be in line to start on Sunday.
Potential Barcelona starting XI: Ter Stegen; Semedo, Pique, Umtiti, Alba; Busquets, Rakitic, Iniesta, Paulinho; Messi, L. Suarez.
|Goalkeepers||Pachecho, Sivera, Landeto|
|Defenders||Vigaray, Duarte, Alexis, Laguardia, Maripan, Litri, Dieguez, Martin|
|Midfielders||Katai, Ibai, Torres, Pedraza, Pina, Manu, Wakaso, Medran, Lopez|
|Forwards||Sobrino, Santos, Guidetta, Bojan, Perez, Munir, Demirovic|
Alaves will be unable to call upon Rodrigo Ely and Thomas Pina, who are both suspended, while Hector Hernandes and Burgui are injured.
Potential Alaves starting XI: Pachecho; Laguardia, Alexis, Martin, Vigaray; Torres, Pina, Ibai, Pedraza; Guidetti, Munir.
BETTING & MATCH ODDS
Barcelona are favourites to win according to dabblebet , who price the Catalan outfit at 1/12. Alaves are rated at 25/1 to upset Barca and a draw is a 10/1 bet.
Barcelona suffered a minor blip when they lost the first leg of their Copa del Rey quarter-final to Espanyol last week, but they remain unbeaten in the Liga after 20 games.
Their performances in the league have catapulted them well ahead of their rivals and they will aim to take another step in their procession towards the title when they host Alaves.
Barca triumphed 2-0 in the corresponding fixture back in August and they have only improved since then, adding quality such as Coutinho to their ranks.
With a Copa del Rey semi-final against Valencia to come just a couple of days later, Ernesto Valverde may opt to rest some players, but the replacements have shown they are up to the task.