Zinedine Zidane's side come into the clash as league leaders and one of only two unbeaten sides left in the Spanish top flight.
Atletico, meanwhile, are a point behind their cross-city rivals and have not lost at home since Real Madrid's last visit back in February.
Atletico Madrid vs Real Madrid Latest Odds
Atletico have an excellent derby record at the Bernabeu in recent years but they have been less convincing in front of their own fans.
Atletico Madrid vs Real Madrid Team News
Alvaro Morata received two yellow cards in quick succession during Atletico's midweek win over Mallorca, meaning he is suspended for the weekend clash with his former side.
Real Madrid are hoping that Luka Modric can return from injury, while they have concerns at left-back with Marcelo and Ferland Mendy both sidelined for their win over Osasuna on Thursday.
Atletico Madrid vs Real Madrid Preview
Matches between these two neighbours tend to be tight affairs and this weekend's clash should be no different.
Los Blancos come into the game having kept back-to-back clean sheets and in their last two league matches they have restricted their opponents to zero shots on target.
Atletico are the most solid side in the division and have kept clean sheets in 11 of their last 15 home La Liga clashes, so opposing a high-scoring game this weekend makes perfect sense with these two sides likely to cancel each other out.
Atletico Madrid vs Real Madrid Tips and Predictions
Under 2.5 goals has paid out in six of the last eight Madrid derbies in La Liga and is offered at the healthy-looking price of 17/20 (1.85).
Odds correct at the time of writing. Please gamble responsibly.