Real Madrid failed to beat Athletic Bilbao last season, drawing 0-0 in the Basque Country and 1-1 at the Bernabeu, and will be out to make amends this time around.
Indeed, Julen Lopetegui's side have begun this La Liga campaign in positive fashion and they will be aiming for a fourth win in their fourth game of the season when they visit San Mames on Saturday night.
Athletic had their last league game at Rayo Vallecano postponed, meaning they have not been in action for nearly three weeks.
Under new manager Eduardo Berizzo, the Basques have claimed a win and a draw in their opening two games and bet365 offer them at 5/1 (6.00).
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Athletic's veteran striker Aritz Aduriz has trained all week and looks to be completely recovered from his muscular injury, whilst Madrid make the trip to the north of the country free of any major injury concerns.
With neither of these clubs having ever been relegated from La Liga, this is one of the most contested fixtures in the top flight.
The visit of the side from the capital is always an occassion at San Mames, and Athletic will aim to make life difficult for Los Blancos once more.
The Basques have netted twice in both of their matches so far this season and boast a strong scoring record against Real Madrid, scoring in six of their last seven clashes.
Madrid have also looked a solid unit this term, with the departure of Cristiano Ronaldo not being felt in terms of goalscoring as the European champions have notched ten strikes in three matches.
Tips and previews
With both teams in seemingly having few problems in the final third, a goals based selection makes sense. Both teams to score and over 2.5 goals is available at 5/6 (1.83) and has paid out in four of the last six meetings.
Prices correct at the time of writing. Please gamble responsibly.