In a top-of-the-table clash, Medeama currently lead the log in Zone A with 19 points, one above Kotoko.
Three points on Sunday will almost certainly guarantee the winners a place in the next round of the championship - the semi-finals.
|Asante Kotoko vs Medeama|
|Date||Sunday, May 19|
Squads & Team News
Kotoko have been boosted by the return of talisman Songne Yacouba, who featured in Wednesday's 1-0 win over Eleven Wonders after two months on the sidelines.
The Burkinabe is likely to be handed his first start of the competition alongside Abdul Safiu Fatawu, who has led the lines in the absence of the former and has registered seven goals so far.
Coach CK Akonnor will also have to find some temporal solution for his midfield problems, having struggled to find a solid central pair since the injury of Richard Senanu during their Caf Confederation Cup campaign.
Medeama's good performances so far has been more about solid team play than individual effort.
That said, the influence of the likes of Justice Blay, Rashid Nortey and Joseph Tetteh Zutah, who are all available for Sunday's clash, cannot go unmentioned.
In attack, Kwame Boateng and Kalibo Dedy Toussaint will be the main men Kotoko will have to keep eyes on.
Sunday's clash will be the second meeting between Kotoko and Medeama in the Special Competition.
In the reverse fixture in Tarkwa, the Yellow and Mauves emerged 1-0 victors at home thanks to a Kwame Boateng penalty.
The top two teams in the zone at the end of the group stage will progress to the semi-finals.
In Zone B, Hearts of Oak, who have already secured qualification for the next round, will face Elmina Sharks at the Accra Sports Stadium as second-positioned Karela United face Dreams FC in Anyinase.