Aaron Ramsey's late winner settled a particularly open game between Arsene Wenger's side and the Premier League champions at the end of last season but it's the Blues that are expected to come out on top this time around.
bet365 make Antonio Conte's side 6/5 (2.20) favourites to win the tie in 90 minutes, the draw is a 5/2 (3.50) shot and Arsenal are the outsiders at 9/4 (3.25) to win in what will be Wenger’s 20th visit to this venue.
They may be second best in the betting, but the Gunners do enjoy a trip to this ground. Unlike their local rivals Spurs, who will be using Wembley as their home ground for the upcoming campaign, the red half of north London have had plenty of success in recent years.
In fact, Arsenal have won their previous seven matches on this hallowed turf, and while the match odds are tough to call with much certainty, it could certainly be an entertaining afternoon for punters to enjoy.
The FA Cup final wasn't the last time these two teams went head-to-head, with Chelsea coming out on top 3-0 in a Beijing friendly just a few weeks ago. That match was the fourth consecutive time that over 2.5 goals has paid out when these two rivals have clashed.
Both teams have certainly had their defensive struggles in their warm up games for the new campaign too. The Blues lost high-scoring pre-season clashes to both Inter Milan and Bayern Munich, but found the net on both occasions. Meanwhile Arsenal lifted the Emirates Cup, scoring six times and conceding three at the other end.
Eden Hazard and Alexis Sanchez might not be on the pitch this weekend but with both teams looking very capable going forward but somewhat lacklustre at the back, it could pay to take a chance on over 2.5 goals and both teams to score, which is priced at 20/21 (1.95) with bet365.