Caf has named referee Hamada el Moussa Nampiandraza to take charge of the Ghana - South Africa clash.
The 30-year-old Knight of the Whistle from Madagascar will be in the centre of affairs as the Black Stars face the Bafana Bafana at the Estadio de Mongomo Tuesday.
He will be assisted by Evarist Menkoune and Songuifolo Yeo from Cameroon and Ivory Coast respectively.
Zambian Janny Sikazwe will be the fourth referee while Zoumaro Gnofame plays the role of Match Commissioner.
Ghana lost their first group game narrowly against Senegal but bounced back to pip Algeria last Friday and South Africa are still winless after two games. The Bafana Bafana are in dire need of the maximum points following a defeat and a draw against Algeria and Senegal.
Meanwhile, Ghana's Malik Alidu Salifu will be one of the assistant referees when Guinea lock horns with Mali on Wednesday.