The Uruguay international had his first taste of one of the world’s great derby clashes in October last year, when he made his official Barca debut in the 3-1 defeat to Madrid at the Bernabeu.
Ahead of the return fixture, the former Liverpool striker says he is still getting used to the fact that he is set to become a Clasico regular.
“I never imagined that I’d play in a game of this magnitude,” he told the club website, adding that this time he hopes for a better result.
“I was focused on my nervousness about coming back to play. Aside from it being a Clasico, it was important for me. I didn’t enjoy it as you should enjoy a Clasico, let’s hope I can do it this time.”
Following a stuttering start to his time in Spain, the 28-year-old has now hit seven Liga goals and four to help Barca into the quarter-finals of the Champions League.
“I’m happy and I feel like I’m really helping the team, something that makes me a lot calmer,” the attacker said.
“There was a time that I was very hard on myself, not just because I wasn’t scoring goals but also because I felt like I wasn’t helping the team, something that worried me. I always knew that the goals would come.”