Tottenham must make sure they do not crumble in the Premier League title race, after suffering a damaging FA Cup semi-final defeat to Chelsea at Wembley.
Spurs were beaten 4-2 by Antonio Conte's men in a pulsating encounter at the weekend, despite appearing to be the better side for the majority of the game.
The clash was billed as potentially pivotal in the Premier League title race, with momentum swinging towards the Premier League leaders, but Spurs must ensure they do not suffer a collapse, with just four points separating them in second and the Blues in first.
As such, Wednesday's game against Crystal Palace offers a chance for Mauricio Pochettino's side to get back on track.
Spurs have no major injury concerns to report, with their main absentees - Harry Winks and Erik Lamela - both long-term.
Danny Rose is nearing a return to action - he has not played since the 0-0 draw with Sunderland in January - but he is expected to feature against Arsenal this weekend, as opposed to Palace.
Rumours persist over Ben Davies' fitness, meanwhile, after the Wales international was only selected on the bench against Chelsea at the weekend.
It has been reported that he may have sustained a knock, leading to Heung-Min Son's selection as a wing-back, but others have speculated that his benching was purely tactical.
Spurs have no players suspended for the encounter with Crystal Palace.
POTENTIAL TOTTENHAM LINE-UP
Pochettino sprung a fair few surprises against Chelsea.
The Argentine opted to select Kieran Trippier at right wing-back instead of Kyle Walker, while Son played on the opposite flank, ahead of Davies.
Son subsequently conceded a penalty during the game, which Willian converted, while Trippier did not offer the same attacking flair as Walker.
The two decisions ultimately backfired on Pochettino, with Son more comfortable further up the pitch, and it remains to be seen if changes will again be made against Palace, with a vital north London derby against Arsenal looming.
Spurs can ill-afford to lose any of their remaining games if they are to catch Chelsea in the Premier League title race, and rotation is likely, with Trippier perhaps retaining his place to save Walker's legs for the clash with the Gunners.
While Jan Vertonghen, Toby Alderweireld and Eric Dier will surely keep their places, Son may be pushed higher, with Davies returning, and Alli or Eriksen potentially dropping to the bench as Pochettino shuffles his pack.
CRYSTAL PALACE TEAM NEWS
Palace defeated Liverpool 2-1 at Anfield on Sunday, but Sam Allardyce has hinted that he will make a number of changes for this week's clash with Spurs.
"I am worried these lads can't reach this level when they don't have time to recover," he said after that victory. "I may have to make huge changes to make sure we compete with Tottenham.
“Thirty-eight points has been safe for a long time, but mathematically we’re not safe."
Defender James Tomkins is a major doubt for the encounter after injuring his ankle against the Reds, and reports have since confirmed that he left Anfield wearing a protective boot.
Scott Dann, Connor Wickham and Pape Souare are also injured.
BEST OPTA MATCH FACTS
Crystal Palace have lost each of their last three league games against Tottenham; they haven't lost four successive games since their first five encounters with Spurs in the top-flight (Aug 1969 - Sept 1971).
Harry Kane has scored 18 goals in 24 London derbies in the Premier League - the Spurs striker has the best goals per game ratio in history in such derbies (0.75 goals per game) of players to play in five or more.
Tottenham haven't won an away top-flight London derby since their last visit to Selhurst Park in January 2016, failing to win each of the last four trips in London (D2 L2)
TV COVERAGE & KICK-OFF TIME
The game is due to kick off at 20:00 on Wednesday and will be televised live on Sky Sports in the UK.