Betway's latest odds see Tottenham at 2/1 (3.00) to win the game as they did in this exact fixture last season, albeit that was their only victory in the last 11 league meetings between the sides.
Games immediately following international breaks can be tricky for punters to assess. That said, Alisson, Roberto Firmino and Fabinho were all rested in Brazil's clash with El Salvador. Mohamed Salah's last involvement for Egypt was on Saturday so they should all be relatively fresh for this game.
Harry Kane was a second half substitute in England's win over Switzerland but Dele Alli and Hugo Lloris are out of the game. Centre backs Toby Alderweireld and Jan Vertonghen both played a full 90 minutes on Tuesday night for Belgium while Moussa Dembele was given a late cameo.
London has been a happy hunting ground for Jurgen Klopp since taking over at Liverpool. The German has seen his side win nine of their 15 trips to the capital in the league but they're yet to win against Tottenham.
Last season the Reds took only one point from five trips to their fellow top six sides. That might put off some who would normally back them in the match odds market, but their defence has improved markedly with the acquisition of Alisson.
Although the goalkeeper was at fault for the goal his side conceded at the King Power Stadium, it was the first in four matches so far this term. It's 13/5 (3.60) with Betway that the visitors keep another clean sheet here.
Goals are usually a given in games between these sides though. There have been 149 scored in head-to-head meetings between them in the Premier League, the second most in the competition behind Arsenal v Everton (151). The 22 penalties awarded in this fixture is also the most of any matchup in Premier League history.
Tips and Predictions
Over 2.5 goals is just 4/6 (1.67) as you’d expect given the history between the pair and both teams to score is 11/20 (1.55) with Betway. Over 3.5 goals is available at 13/8 (2.63) with the same firm.
Instead, punters should look to Liverpool's attack which has been well treated by their respective international managers. The Reds are 19/20 (1.95) to score twice (over 1.5 team goals) and that looks a selection well worthy of consideration.
Spurs have conceded in three of their four Premier League games to date and Manchester United missed several good chances in the other.
Given how many of Mauricio Pochettino's defensive players were involved on Tuesday night, it would be no surprise if they struggled to contain the dynamic trio of Salah, Firmino and Sadio Mane who have already accounted for seven goals between them this season. The absence of Lloris is as a big blow to their chances too.
With Pochettino failing to bring in any reinforcements over the summer, this looks a very tough turnaround for those involved midweek so backing the well-rested Reds to find plenty more joy in front of goal looks the best option.