Arsenal winger Theo Walcott has been dropped to the bench for the meeting with Watford, with Danny Welbeck not selected in the matchday squad.
The duo starred for the Gunners in their FA Cup win over Southampton, with Welbeck scoring twice and Walcott netting a hat-trick against his former club.
Olivier Giroud is instead preferred in attack for the north Londoners, while the likes of Alexis Sanchez and Mesut Ozil are also recalled to the starting XI.
Nigeria international Alex Iwobi is another to be recalled by Arsene Wenger, with the 20-year-old only appearing as a second-half substitute on Saturday.
Watford, meanwhile, make nine changes to the side that last to Millwall in the FA Cup, handing a debut to on-loan AC Milan striker M'Baye Niang.
The Gunners have won their last four matches in all competitions and will be looking for all three points as they look to keep pace with current league leaders Chelsea.
Wenger's side beat the Hornets in the reverse fixture back in August 2016, with Santi Cazorla, Alexis and Ozil on the scoresheet for the visitors that day.