The Brazilian is absent after picking up a niggle in the 3-1 victory over Arsenal last Saturday, which resulted in him missing the week’s sessions.
That allows Origi to make a first Premier League start since the 1-1 draw with Manchester United at Old Trafford in mid-January.
Lovren, meanwhile, was on the bench against the Gunners having shaken off a knee injury, but is again unavailable.
Ragnar Klavan continues alongside Joel Matip, with Joe Gomez providing cover if needed at centre-back.
Harry Wilson, 19, is named in reserve for the first time in the Premier League. He made his Liverpool debut in the 1-0 FA Cup replay victory over Plymouth Argyle, replacing Philippe Coutinho on 65 minutes.
Wilson was an unused substitute as the Reds exited the competition after the 2-1 defeat to Wolves.
Liverpool starting XI: Mignolet, Clyne, Klavan, Matip, Milner, Can, Wijnaldum, Lallana, Mane, Coutinho, Origi
Liverpool subs: Karius, Gomez, Moreno, Lucas, Alexander-Arnold, Woodburn, Wilson