Having won 11 and lost none of their 13 previous encounters with this opposition, they are overwhelming 1/7 (1.14) favourites with SportPesa to move one step closer to more silverware by coming out on top in Wales.
Eliminated in six of their last seven FA Cup ties against Premier League opponents, the Swans are priced at 13/1 (14.00) to pull off a shock win and reach the semi-finals for the first time since 1964.
Neither side has played out a draw in this season's competition, although you can get odds of 25/4 (7.25) on them taking this clash into extra-time after a deadlocked 90 minutes.
Oli McBurnie will hope to return after missing the last couple of matches due to illness, while Joe Rodon, Leroy Fer and Martin Olsson are all ruled out due to injury.
Vincent Kompany could return after missing the Schalke match with a minor injury, although Fernandinho, Kevin De Bruyne, Benjamin Mendy and Claudio Bravo remain sidelined.
While no reminder of the English champions' quality was really needed, the Citizens' 7-0 mauling of Schalke will have been difficult to watch for Graham Potter and his players.
Having conceded at least once in eight of their last 10 matches, it is certainly hard to see the Championship outfit containing an opponent in full confidence and averaging over five goals a game in this season's FA Cup.
With Swansea's three matches in this season's competition having produced a total of 13 goals, odds of 20/21 (1.95) look like solid value on at least four going in when they take on a rampant Manchester City.