Last season La Real beat Los Rojiblancos 3-0 when they met in San Sebastian, while the season before that the Basques triumphed by a 2-0 scoreline. La Real come into this weekend's game on a 10-match unbeaten run in all competitions and will be looking to make life tough once more for the side from the capital.
Defender Lucas Hernandez will be missing for Atletico at Anoeta, will Diego Costa, Nikola Kalinic and Stefan Savic could be doubts with all three missing training at some point this week.
The hosts for their part are missing midfielder Asier Illarramendi with winger Adnan Januzaj also a doubt with an ankle problem.
Atletico have been far from prolific on the road, while La Real have scored more goals away from home than in front of their own fans. The respective records of the two sides therefore go some way to explaining the price of 1/2 (1.50) for under 2.5 goals in a game that is expected to be pretty tight.
Simeone's men - as ever - boast the best defensive record in the Primera Division, while only three teams have conceded fewer goals than Real Sociedad with the Basques keeping four clean sheets in their last five league games.
Tips and predictions
Under 2.5 goals and both teams to score 'no' is offered at 17/20 (1.85) and has proved a regular winner in both sides' recent matches, as well as paying out five of the last eight times this fixture has been contested.