Zinedine Zidane's side have far less to play for than the team currently bottom of the Spanish top flight, although the hosts will still want to put in a good performance in what will be the second match since the Frenchman returned to the helm.
Huesca are the biggest priced team in La Liga this weekend offered at 18/1 (19.00) with bet365 to claim three points.
Watch and bet live on Real Madrid vs Huesca
bet365 customers in the UK can watch and bet live on this fixture. Your account must be funded or active (have placed a bet in the last 24 hours) to enjoy the action.
Right-back Dani Carvajal and winger Vinicius Junior remain injured for the hosts. Huesca for their part have winger David Ferreiro suspended while midfielder Gonzalo Melero and full-back Luisinho are out.
Throughout the season, Huesca have been better than their results have suggested. The side from the region of Aragon have managed to score away at every team they have faced in the top seven (except Atletico Madrid), scoring at Barcelona, Getafe, Sevilla and Valencia.
Real Madrid have conceded in nine of their last 10 matches in all competitions, and while they did keep a clean sheet in their last game against Celta Vigo, they still afforded the division's most out-of-form side a couple of good chances to score.
Los Blancos should be able to see off Huesca, but there could be some value in backing the visitors to find the back of the net.
Tips and predictions
Both teams to score is priced at 19/20 (1.95) while goals at both ends and over 2.5 strikes in the clash is offered at 11/10 (2.10) and that looks the best way to go for punters. Also of interest could be the price of 8/11 (1.73) for Real Madrid to win a game with over 3.5 goals.
Odds correct at the time of writing. Please gamble responsibly.