The Catalans recorded a famous 2-1 victory when the two sides met at the Estadio Montilivi in October and Pablo Machin's side will be hoping for another positive result in their first ever trip to the Bernabeu.
Girona are having an exceptional campaign in their debut season in La Liga and begin the weekend in seventh place.
The draw, which would be the visitors' eighth of the campaign, can be backed at 6/1 (7.00).
Girona have goalkeeper Gorka Iraizoz back from injury, although left-back Carles Planas remains unavailable.
Real Madrid have no injury concerns ahead of the game.
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Los Blancos struggling for clean sheets
Real Madrid's defensive record in La Liga has been far from impressive this term, with the defending champions keeping just one clean sheet in their last 13 league matches.
Indeed, eight teams have conceded fewer goals at home than a Real Madrid side who have let in 14 strikes in their 14 league games at the Bernabeu this season.