Zinedine Zidane's side remain focused on the Champions League final in two weeks time, while Celta are limping to a disappointing end of the season.
Indeed, their hopes of securing European football have been dashed by their current run of one win in nine matches.
Last season, Celta claimed a famous 2-1 win in the Spanish capital as they knocked Los Blancos out of the Copa del Rey.
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Zinedine Zidane rested a number of players for the midweek trip to Sevilla and may further rotate his squad.
Cristiano Ronaldo and Dani Carvajal will be missing through injury, although Gareth Bale is available after being suspended on Wednesday night.
Celta should welcome back top scorer Iago Aspas after nearly a month out, although it remains to be seen whether he will be on the bench or in the starting eleven.
With little on the line for either side we are likely to see a game lacking in intensity.
Ronaldo has been vital to Real Madrid's attacking play this term, scoring 30 per cent of Real Madrid's league goals, and without him in the side Madrid look considerably less dangerous.
As well, the visitors have been extremely poor in the final third - netting just twice in their last six matches - and there is little reason for us to imagine that they will contribute to a high scoring game.
Tips and predictions
This selection has paid out in Madrid's last three home league matches, as well as in eight of Celta's last nine games away from Balaidos.