The Champions League is now Los Blancos' final shot at redemption in a season that has been characterised by disappointment.
Zinedine Zidane's men recorded a 3-1 victory in the first leg at the Santiago Bernabeu in February and they will look to take advantage of the fact that PSG are without their talisman.
Despite being without the Brazilian, the hosts will be buoyed by the fact that they managed to secure an away goal in Madrid and they will be confident of getting a result at home.
|Game||PSG vs Real Madrid|
|Date||Tuesday March 6|
|Time||19:45 GMT / 14:45 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Fox Sports 1||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 2 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
Squads & Team News
|Goalkeepers||Trapp, Areola, Cibois|
|Defenders||Silva, Kimpembe, Marquinhos, Meunier, Yuri, Kurzawa, Alves|
|Midfielders||Verratti, Motta, Di Maria, Lo Celso, Diarra, Draxler, Nkunku, Rabiot, Pastore|
PSG have announced a 21-man squad for the match and the most notable absentee is Neymar, who suffered an ankle injury last week.
There were slight concerns over Kylian Mbappe and Marquinhos but both players are deemed fit enough.
Potential PSG starting XI: Areola; Alves, Marquinhos, Kimpembe, Kurzawa; Verratti, Rabiot, Lo Celso; Di Maria, Mbappe, Cavani.
|Position||Real Madrid players|
|Goalkeepers||Navas, Casilla, Luca|
|Defenders||Carvajal, Vallejo, Ramos, Varane, Nacho, Marcelo, Theo, Achraf|
|Midfielders||Kroos, Modric, Bale, Casemiro, Llorente, Isco, Asensio, Kovacic, Ceballos|
|Forwards||Ronaldo, Benzema, Mayoral, Vazquez|
Luka Modric and Toni Kroos have been included in the panel for the trip to Paris as has Cristiano Ronaldo, who was a slight concern after the weekend.
Potential Real Madrid starting XI: Navas; Carvajal, Ramos, Varane, Marcelo; Casemiro, Modric, Asensio, Bale; Ronaldo, Benzema.
Betting & Match Odds
PSG are 10/11 favourites to win the match according to dabblebet, but whether that will be enough to see them qualify is another matter. Real Madrid are priced at 12/5 to win and a draw is available at 14/5.
While PSG are favourites to win on the evening, the odds are in favour of Madrid to qualify at 1/4, but the hosts are deemed less likely to do so at 11/4.
PSG began this season as one of the favourites to win the Champions League, but their hopes of upsetting the usual suspects are currently hanging by a thread.
Cristiano Ronaldo continued his dominance of Europe's premier club competition with a record-breaking display in the first leg to fire Real Madrid into a comfortable lead and PSG's task of overturning that result has been made more difficult by the fact that their star man is unavailable.
However, one man who is intimately familiar with Madrid and who knows what it takes to beat them is Dani Alves. And the PSG full-back has issued a rallying cry to his team-mates to overcome the odds and write a new chapter in the club's history.
"What are PSG missing? Matches like this to show that Paris is not all about money," the former Barcelona defender told reporters. "I came here because I am a competitor – it's in my blood. And being part of the history of the club isn't something you can buy.
"If I speak to the squad, I'll say we have to seize this important moment. History is there to be changed."
While PSG may be inspired by a defiant urge to cement their place in Europe's elite, they come up against a Real Madrid side who have their hearts set on making more history of their own by winning three Champions League titles in a row. Indeed, Los Blancos' season will now be defined by their Champions League performance, so Tuesday's game will be a true battle of will.