The seven-time AFCON champions have not faced a European team since beating Bosnia in a friendly in 2014, and a game against the winners of Euro 2016 should be a useful exercise for them too.
Cristiano Ronaldo has been called up and the Real Madrid forward will be captaining the side.
It could be an intriguing contest between Ronaldo who is the top scorer in La Liga in 2018 and Egypt's Mohamed Salah, who leads the Premier League's scoring charts this season.
Both players are expected to start on Friday evening in strong lineups.
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Value in both teams to score
It is worth remembering that this friendly is being played in a neutral venue and Portugal's record in friendlies played away from on home soil is not particularly strong.
The side have lost two of their last three away friendlies, and while they are still favourites, there could be some value in backing the Egyptians to get on the scoresheet.
Tips and predictions
Both teams to score is priced at 23/20 (2.15) and this looks to be extremely generous.
Any time both teams to score is offered at better than evens it is worth considering as an option, especially considering the form of Salah for Liverpool this season.