Having dropped points with a goalless draw against FC Cologne last weekend, Dortmund needed all three points as Hoffenheim came to town in the battle for third place.
The hosts got the start they were hoping for at the Westfalenstadion as Marco Reus opened the scoring-albeit from an apparent offside position-for the hosts only four minutes into the proceedings.
Despite missing a 15th-minute penalty, Aubameyang eventually got his name on the scoresheet with a header into the empty net after Raphael Guerreiro’s initial effort struck the post in the 82nd minute.
With the strike, the 27-year-old looks to have secured automatic Champions League qualification for Thomas Tuchel’s men, whilst he also drew level in the scoring charts with biggest rival Robert Lewandowski.
With just two matches to spare until the end of the season, the two forwards remain level with 28 goals apiece heading into the final two weeks of the Bundesliga season.
Aubameyang has already eclipsed his career-best return of 25 goals from last season as he sits on 28 goals from just 30 appearances.
Bayern Munich's Lewandowski finished the 2015-16 campaign with 30 goals, and became the first foreign player to hit the 30-goal mark in Bundesliga history and also the first player since 1976/77 to score 30 goals in a single Bundesliga campaign.
Auba could also engrave his name in the history books by becoming only the second foreign player and first African to reach the milestone should he score two goals in his final two matches.