Mauricio Pochettino's team have been beaten in just two of their last 15 fixtures in all competitions and are chalked up as red-hot 1/6 (1.17) favourites with bet365.
Newport will not come into this clash entirely bereft of belief but are still offered at 14/1 (15.0) to pull off an enormous upset by seeing off Spurs.
The draw is priced at 13/2 (7.50), which would see Michael Flynn's side earn a replay at Wembley.
Dele Alli, Heung-Min Son and Christian Eriksen were substitutes in the previous round and Mauricio Pochettino may well afford a breather to some of his key men again here.
The League Two team should be at full-strength for this clash and player-manager Flynn is likely to resist the temptation to field himself against the Premier League outfit.
Spurs to win comfortably
Five of Spurs' last six victories has seen the north Londoners record a clean sheet and bet365 offer 8/11 (1.72) that Spurs shut out the hosts..
Tottenham have won by at least three clear goals in four of their last five victories and the 11/10 (2.10) quote for Spurs (-2) in the handicap market could well represent good value.
Tips and predictions
Newport will feel that a famous victory is possible after beating Leeds United in the last round, but Spurs should make short work of the team from the fourth tier of English football.
bet365's 11/10 (2.10) quote for Pochettino's team to win by at least three clear goals could well prove profitable for punters ahead of Saturday's Cup clash.
Odds correct at time of writing. Please gamble responsibly