Newcastle meanwhile were knocked out of the cup by Watford, and now Rafa Benitez's men will be focusing all their efforts on avoiding relegation.
The Magpies have won just three of their 12 home league games this term and SportPesa price them at 13/1 (14.00) to pick up three points on Tuesday.
City suffered successive away defeats in the league last month at Chelsea and Leicester although they have won both subsequent games on the road. The visitors are priced at 4/19 (1.21) with the draw at 25/4 (7.25).
Benjamin Mendy made his comeback from ten weeks out in the Carabao Cup win over Burton last week but missed the weekend win over Burnley with a knee problem, making him a doubt for Tuesday. Vincent Kompany is likely to absent.
Newcastle have midfielder Ki Sung-Yeung out with a hamstring problem.
City's start to 2019 has been exceptional with Guardiola's men winning all seven games they have contested, netting an extraordinary 30 goals in that time.
The only goal they have conceded this year came in their first game against Liverpool, with the Citizens keeping six consecutive clean sheets.
There must surely be a temptation to back the champions to keep another clean sheet against a Newcastle side who have the third-worst home scoring record in the division - scoring just ten times in 12 home league games.
Tips and predictions
City to win to nil is priced at 20/23 (1.87) and looks like an extremely strong selection for this game, with this bet paying out in three of City's last four league visits to Newcastle.