Needing just one more goal to overtake Eric Brook as the Citizens' all-time record scorer, the Argentina international is available at 15/4 (4.75) with bet365 to do so in style by breaking the deadlock at the Stadio San Paolo.
However, Pep Guardiola's rotation policy means that is far from guaranteed, with Gabriel Jesus chosen ahead of Aguero both in the reverse fixture and for Saturday's league win over West Brom.
Having scored the second of his side's two goals in the 2-1 victory two weeks ago, the Brazilian forward is also on offer at 10/11 (1.91) to get on the scoresheet once again.
Also on target in the last encounter, Raheem Sterling looks like the best value at 2/1 (3.00) considering he has struck nine goals in just eight starts this campaign, and similarly Leroy Sane could offer plenty of temptation at 6/4 (2.50) after finding the net eight times in nine starts himself.
At the other end of the pitch, Dries Mertens will be determined to make up for missing a penalty in Manchester, and can be backed at 10/3 (4.33) to open the scoring.
Having each struck twice in the Champions League so far, Lorenzo Insigne 15/8 (2.88) and Jose Callejon 15/8 (2.88) are probably the most likely candidates aside from Mertens to strike for the Maurizio Sarri’s team, and Marek Hamsik can be backed at 11/4 (3.75) to finally grab the goal that would pull him level with Diego Maradona as the Partenopei’s all-time top goalscorer.