Didier Deschamps' men suffered an agonising defeat in the final of this competition on home soil back in 2016, but atoned for that disappointment in spectacular style last summer when they were crowned as world champions in Russia.
Indeed, 888Sport offer just 2/15 (1.13) that France kick off their campaign with victory in the Moldovan capital. Alexandru Spiridon's side are a 22/1 (23.0) chance to stun the world champions in Chisinau.
The odds compilers offer 17/2 (9.50) that Moldova manage to procure a point from Friday's fixture against Les Bleus.
Aymeric Laporte and Alexandre Lacazette were eye-catching absentees from the France squad. Barcelona star, Ousmane Dembele, misses out through injury. Kingsley Coman is back in the fold for the first time since 2017.
Goals at a premium
Each of Moldova's last six fixtures has featured fewer than three goals but 888Sport offer 17/10 (2.70) that the trend continues on this occasion when the World Cup winners visit.
The same firm go 4/9 (1.44) that the hosts draw a blank against their more illustrious opponents. Moldova have scored just four goals in their last eight games - three against San Marino and one against Luxembourg.
France to win well
Moldova have won only three of their last 29 fixtures and all were against San Marino. In complete contrast, France have lost just two of their last 25 matches and so this appears to be a complete mismatch.
The 5/2 (3.50) quote from 888Sport for France to win by at least four goals in the Moldovan capital appears to represent reasonable value. The same firm go 9/2 (5.50) that the world champions score at least five times.
Les Bleus, though, have not scored five goals in a competitive match for almost three years. The odds compilers offer 13/20 (1.65) that the French are frustrated, with fewer than two goals scored before the break.
It would take a brave punter to back against Les Bleus in Friday's fixture. Deschamps' men will be determined to lay down a significant marker in their opening Euro 2020 qualifier.
It is, therefore, the even money (2.0) quote for France (-2) that could carry most appeal here. Moldova suffered a humiliating 4-0 defeat at Luxembourg last September and Friday's fixture could be another long evening for Spiridon's side in Chisinau.