Spectacular goals from Nabil Fekir and Memphis Depay either side of a blistering Layvin Kurzawa volley gave Lyon a 2-1 victory, inflicting only a second top-flight defeat of the season on Unai Emery's table-toppers.
But thoughts post-match turned towards Mbappe, with the teenager having received lengthy treatment on the field during the first half after pursuing Marco Verratti's raking pass and colliding with the on-rushing Lopes.
PSG's club doctor Eric Rolland reported the ex-Monaco favourite's injury was "nothing serious" and Mbappe later posted on Twitter to offer further reassurances.
"Just a message to tell you that I'm fine," he tweeted.
"It was more fear than harm despite the impressive shock – without a grudge, A. Lopes.
"And thank you for all your messages."