With just one defeat to their name in 17 league fixtures, Rudi Garcia's men are currently sitting a point clear of their guests in third place.
Having succumbed to a humiliating 6-1 defeat at the Stade Louis II in August's reverse encounter, they are available at 19/20 (1.95) with dabblebet to exact revenge.
That win was a fourth in successive league meetings between the teams for Les Rouges et Blancs, who can be backed at 14/5 (3.80) to make it five in a row here.
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Morgan Sanson returned from injury to score the second goal in Wednesday's cup win over Epinal, although Jorgan Amavi remains sidelined.
Leonardo Jardim is hoping to welcome back defender Jemerson from injury, while Thomas Lemar, Joao Moutinho and Danijel Subasic should also return after being rested in the cup defeat at Lyon.
Defences on top
That 6-1 defeat will certainly feel like a very long time ago for Garcia's team, who have gone from strength to strength ever since.
Having kept five consecutive clean sheets coming into this clash and conceded just once in their last seven home games, it is hard to see them collapsing in the same manner this time.
Instead, the game looks set to be a far tighter affair, with the champions also holding strong at the back after conceding just twice in their last five Ligue 1 matches on the road.
Tips and Predictions
All in all, odds of 21/20 (2.05) appear to offer generous value on under 2.5 goals for Monaco's fifth league away game in six, as well as a fifth match in six for Marseille.