Manchester United can book their place in the Champions League knockout stages when they welcome Young Boys to Old Trafford on Tuesday.
The Red Devils will progress to the last 16 if they collect maximum points and Valencia fail to overcome Juventus in Turin in the other Group H game.
Having run out comfortable 3-0 winners in the reverse fixture in Bern, they are clear 1/4 (1.25) favourites with William Hill to fulfil their part of the bargain by coming out on top once again.
Gerardo Seoane’s team need a victory to have any chance of finishing third and taking their place in the Europa League, but are 11/1 (12.00) long shots to pull off a shock win here.
The hosts were held to a frustrating 0-0 draw at home to Crystal Palace on Saturday, and there are odds of 24/5 (5.80) on them being forced to settle for a single point yet again in this one.
Victor Lindelof is a doubt after coming off with a groin injury at the weekend, while Diego Dalot is ruled out.
Gregory Wuthrich is unavailable due to a damaged thigh, with long term absentee Jordan Lotomba also still missing due to a knee injury.
Saturday’s goalless stalemate was not the first frustrating 90 minutes that the Old Trafford crowd have had to endure this season, with their team failing to score in four of the last eight matches on home turf – including both Champions League games.
However, they are unlikely to have similar problems against a visiting side that has conceded 28 times in their last nine away matches in this competition and only kept one clean sheet in 11.
What’s more, Jose Mourinho’s side should have little trouble in keeping at bay an opposition attack that has only scored twice in their four group games so far, with 10/11 (1.91) odds providing strong value on them monopolising the goalmouth action.