Jose Mourinho's side are in a fight to secure a second-place finish as they attempt to delay the coronation of their rivals Manchester City for as long as possible.
Should United win their game against the Swans on Saturday and City beat Everton later that evening a derby spectacle the following week could see Pep Guardiola's side clinch the title.
The Welsh visitors, meanwhile, are in a desperate fight to avoid being sucked back into the relegation quagmire, with just three points separating the 14th-placed side from the drop zone.
|Game||Manchester United vs Swansea City|
|Date||Saturday, March 31|
|Time||15:00 BST / 10:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game cannot be watched live on TV due to the UK-wide black-out that is in force for 15:00 kick-offs. However it can be followed live on Goal here.
|UK TV channel||Online stream|
Squads & Team News
|Position||Manchester United players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Bailly, Blind, Darmian, Jones, Lindelof, Rojo, Shaw, Smalling, Valencia|
|Midfielders||Carrick, Fellaini, Gomes, Hamilton, Herrera, Lingard, Mata, Matic, McTominay, Pogba, Young|
|Forwards||Sanchez, Lukaku, Martial, Rashford|
The Red Devils are expected to be without the services of Phil Jones, Daley Blind and Ander Herrera, while Scott McTominay and Sergio Romero picked up knocks while on international duty.
Zlatan Ibrahimovic, meanwhile, has left the club in order to join Major League Soccer side LA Galaxy.
Potential Man Utd starting XI: De Gea; Young, Bailly, Smalling, Valencia; Matic, Pogba, Mata, Lingard, Martial; Lukaku.
|Goalkeepers||Fabianski, Nordfeldt, Mulder|
|Defenders||Van der Hoorn, Mawson, Olsson, Rangel, Naughton, Bartley, Fernandez|
|Midfielders||Ki, Britton, Fer, Dyer, Carroll, Routledge, Clucas, King, Sanches, Maric, James, Roberts, Byers|
|Forwards||Bony, Abraham, Narsingh, J. Ayew, A. Ayew, Baker-Richardson|
Swansea will be without Jordan Ayew, who is suspended, while Leroy Fer and Wilfried Bony are sidelined with injuries. Renato Sanches and Angel Rangel are doubts.
Potential Swansea starting XI: Fabianksi; Olsson, Naughton, Mawson, Bartley, Van der Hoorn; Ki, Carroll, Clucas, Dyer; Abraham.
Betting & Match Odds
Man United are the favourites to win according to dabblebet, who price the Red Devils at 1/4, while Swansea are rated a long-shot at 14/1. A draw is available at 9/2.
Things had been looking good for Mourinho and Man United following their hard-fought win over rivals Liverpool mid-way through March, but a Champions League exit to Sevilla at home a few days later altered the complexion of life at Old Trafford.
The Red Devils boss has been forced to endure a backlash from supporters since then and he showed some signs that the pressure was getting to him when he came out fighting in a scathing critique of his own club's continental pedigree.
On Saturday he comes up against his compatriot Carlos Carvalhal and the Portuguese's perception of the former Real Madrid boss is markedly different to that currently held by Man United fans.
"He is our king of football," Carvalhal told a pre-match news conference. "He opened the doors for the new generation of managers to go abroad.
"He's a fighter - what I mean is he's very good at mind games. The way he acts, he likes the theatre of it, and he usually wins all these battles. I am completely different, I prefer to be out of the theatre."
It remains to be seen whether Mourinho will ultimately win this battle, but he will be forgiven if he allows one eye to drift towards a greater challenge further down the road: preventing Manchester City from winning the title in the derby.