The game will see the return of Cristiano Ronaldo to his former club, but there will be very little room for niceties as he plots a way to take three points back to Turin.
Victory for the Bianconeri would take them further clear at the top of the group, having already beaten Valencia and Young Boys.
United, who defeated Young Boys before playing out a draw at home to Valencia, could leapfrog the Serie A side with a win.
|Game||Manchester United vs Juventus|
|Date||Tuesday, October 23|
|Time||8pm BST / 3pm ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 2 and it can be streamed online via the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
Squads & Team News
|Position||Man Utd squad|
|Goalkeepers||De Gea, Romero, Grant|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Dalot, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Pereira, Fred, Young, Herrera, Fellaini, Matic, Garner, McTominay, Hamilton|
|Forwards||Sanchez, Lukaku, Rashford, Martial, Chong|
Alexis Sanchez did not train ahead of the match and forms no part of the matchday squad, with speculation mounting about his future at the club.
Sanchez is not the only absentee, however, with Diogo Dalot, Marouane Fellaini and Jesse Lingard also missing, while Antonio Valencia is still sidelined.
Talented teenager Tahith Chong makes his first appearance in Mourinho's ranks for a competitive fixture.
Man Utd XI: De Gea; Young, Lindelof, Smalling, Shaw; Pogba, Matic, Mata; Rashford, Martial, Lukaku.
Subs: Romero, Bailly, Darmian, Fred, Perreira, Herrera, Chong.
|Goalkeepers||Szczesny, Pinsoglio, Perin|
|Defenders||De Sciglio, Chiellini, Benatia, Sandro, Barzagli, Bonucci, Cancelo, Rugani|
|Midfielders||Pjanic, Khedira, Matuidi, Can, Bentancur, Bernardeschi|
|Forwards||Ronaldo, Dybala, Costa, Cuadrado, Mandzukic, Kean|
Juventus will be without Mario Mandzukic, who is unavailable due to an ankle sprain, while Emre Can has also been ruled out.
Sami Khedira is unavailable, but Ronaldo is free to take part after only landing a one-match ban for a red card picked up on matchday one against Valencia.
Juventus XI: Szczesny; Cancelo, Chiellini, Bonucci, Sandro; Matuidi, Bentancur, Pjanic; Cuadrado, Dybala, Ronaldo.
Subs: De Sciglio, Benatia, Costa, Barzagli, Kean, Perin, Bernardeschi.
Betting & Match Odds
Juventus are favourites to win according to bet365 , who rate their chances at 6/4. Man United's chances of winning are priced at 21/10 and a draw is available at 23/10.
In Juventus, Manchester United come up against a team considered to be one of the favourites to win this season's Champions League and they will have to be at their very best to overcome the Serie A champions, but, of course, that is easier said than done.
The acquisition of Ronaldo - who is sometimes affectionately known by his fans as 'Mr Champions League' - during the summer has naturally had a marked effect on the perception of Juve's chances in the competition, but the Portuguese is backed up by a glittering supporting cast, which includes the likes of Paulo Dybala, Miralem Pjanic and Leonardo Bonucci.
"They have a lot to offer and an extra year with the same coach and structure," said United boss Jose Mourinho at the pre-match press conference. "They have won seven titles on the trot and a really special player who makes a real difference [Cristiano Ronaldo].
"They are more than a contender for the Champions League."
That United's season has been fraught with difficulty both on and off the pitch does not help their cause either and, despite appearing to turn things round on the pitch in recent weeks, Mourinho now has a fresh issue to contend with as Sanchez looks to have grown disillusioned at Old Trafford.
The remainder of the somewhat depleted squad will have to band together amid the ongoing undercurrent of negativity as they attempt to deliver a blow to Massimiliano Allegri's men.