United are seven points adrift of fourth place Tottenham and 7/2 (4.50) at 888Sport to finish in the Champions League places. Palace on the other hand, are only outside the relegation zone on goal difference.
There are key absentees on both sides. Paul Pogba, Romelu Lukaku and Marcus Rashford are all doubts while Marouane Fellaini and Anthony Martial are back in training despite withdrawing from their respective international squads.
Palace are still without influential defender Scott Dann. Striker Christian Benteke is also absent after surgery on his knee and is expected to be out until January.
Manchester United have usually enjoyed squaring off against the Eagles. The hosts have never lost in the Premier League against Palace, winning 15 of their 18 top flight encounters. That’s more than any team has ever played against a single opponent in the competition without tasting defeat.
While historically this has been a favourable match-up, United's defensive issues have been well documented this term. They've scored but also conceded in each of their last eight Premier League matches with seven of those going over 2.5 goals too.
The Eagles have scored just eight times this season, but they've often saved their best performances for their clashes with the league's best teams.
Tips and Predictions
Neither team to keep a clean sheet at Old Trafford looks worth backing at Evens (2.0) despite Palace's issues in the final third.
Although ranking in the bottom three teams for goals scored in the Premier League, Hodgson's side found the net twice against Arsenal and once at Stamford Bridge - not to mention goals on the road against high-flying Bournemouth and Watford.
At the prices, it's simply too tough to expect Manchester United to discover some defensive steel when they've already leaked 21 times in 12 games.
At Evens (2.0) with 888Sport, both teams to score looks the best bet as these teams look to kick-start their disappointing campaigns going into the festive season.