Victory over their neighbours would see Pep Guardiola’s men crowned champions with six games to spare – more than any other side in the history of English top flight football.
Having run out 2-1 winners at Old Trafford in December’s reverse fixture, they are available at 19/20 (1.95) with dabblebet to hold the trophy aloft with another victory here.
However, the Red Devils have won four consecutive matches in the league, and are priced at 3/1 (4.00) to spoil the party by coming out on top on enemy soil.
The sides shared a 0-0 draw when they met on this ground last season, and you can get odds of 13/5 (3.60) on them cancelling each other out once again in this one.
Similarly, Daley Blind and Phil Jones are the only players unavailable to Jose Mourinho, who otherwise has a fully fit squad to choose from.
Although bound to claim the Premier League trophy sooner or later, the Citizens will be particularly keen to lift it against their closest rivals after suffering a chastening defeat at Anfield.
While many suggested they may rest some key players and prioritise next week’s second leg, the performance in Liverpool will only make the leaders more determined to bounce straight back in this game.
Having won 14 consecutive league matches in front of their own fans, City will be confident of securing a second win of the season against a United team that has lost two of their last three on the road.
As such, the 19/20 (1.95) odds seem like strong value for a team that has been so dominant this season.