Goals from David Silva and Sergio Aguero enabled City to overcome Premier League rivals at the Riverside Stadium.
They are now looking forward to a day out at Wembley in the last four, while chasing down a first success in the FA Cup since 2011.
Guardiola will be determined to get his hands on silverware in his first season in England, with success having followed him wherever he has been.
He has specialised in title triumphs, but his record in knockout competitions is also among the best in the business.
8 - Pep Guardiola has reached a semi-final in all eight of his seasons in senior club management. Business. pic.twitter.com/bxFA5sCmnH— OptaJoe (@OptaJoe) March 11, 2017
He also tasted domestic cup glory at Bayern Munich, with the DFB-Pokal secured in 2013-14 and 2015-16.
City acquired his services hoping to replicate the triumphs of his past, and they are now within sight of a major final appearance.