Captain Jordan Henderson is restored to the centre of the park having been rested in the 7-0 Champions League victory over Maribor, in which the club’s vice-skipper turned in a tempo-setting display.
Milner has been rewarded for that fine showing with Sunday’s test at Wembley the first time he's made consecutive starts this season and represents only his fourth run out from the off in all competitions.
Jurgen Klopp’s two other expected changes are at the back, where Simon Mignolet resumes goalkeeping duties and Joe Gomez slots in for Trent Alexander-Arnold at right-back.
Wijnaldum’s absence sees Marko Grujic named among the substitutes, while Alex Oxlade-Chamberlain could mark the 250th appearance of his club career if he is introduced off the bench.
For the hosts, Heung-Min Son makes a rare start to the left of Harry Kane, with Christian Eriksen setting up on the right side of the attacking trio.
In midfield, youngster Harry Winks lines up for his boyhood club alongside Dele Alli with Victor Wanyama and Mousa Dembele still out through injury.
Tottenham XI: Lloris, Trippier, Alderweireld, Sanchez, Vertonghen, Aurier, Winks, Dele, Eriksen, Son, Kane.
Tottenham subs: Vorm, Rose, Davies, Dier, Sissoko, Nkoudou, Llorente.
Liverpool starting XI: Mignolet, Gomez, Matip, Lovren, Moreno, Henderson, Can, Milner, Coutinho, Salah, Firmino.
Liverpool subs: Karius, Alexander-Arnold, Klavan, Chamberlain, Grujic, Solanke, Sturridge.