The Reds are still unbeaten on home soil in the Premier League this season (15 games), with title-chasing Manchester City the only other side in the division able to match that record.
Victory in their latest outing would allow Jurgen Klopp's side to cement a standing inside the top four and take advantage of those around them being either on an enforced break or in FA Cup action.
Here, Goal takes a look at everything you need to know ahead of the game.
Nathaniel Clyne has worked his way back into contention following a lengthy spell on the sidelines, but Klopp is reluctant to ask too much of him and risk suffering another setback.
Georginio Wijnaldum and Jordan Henderson were only fit enough for bench duty last time out at Old Trafford, but both could be rotated back into the starting XI against the Hornets.
Adam Lallana faces a race against time to prove his fitness ahead of the game, with the injury-ravaged midfielder having been forced to sit out training again in midweek.
Liverpool do not have any suspended players ahead of the tie.
Liverpool potential starting line-up
Jurgen Klopp may decide to keep faith with those who battled bravely against United, only to come away on the wrong end of a 2-1 defeat.
The Reds did struggle to create chances at Old Trafford, but they have been formidable at home this season and will aware of the benefits a settled side can bring.
Watford team news
Watford have 10 players currently unavailable for a variety of reasons, which is posing quite the selection headache to manager Javi Gracia.
Gerard Deulofeu, Tom Cleverley, Younes Kaboul, Nathaniel Chalobah and Jerome Sinclair are among those on the sidelines, while goalkeeper Heurelho Gomes was dropped from the matchday squad for a 3-0 defeat at Arsenal.
TV channel & kick-off time
The fixture will be broadcast live in the UK (United Kingdom) on BT SPORT 1 or BT SPORT 4K UHD from 17:00 GMT.
In the United States, the game can be watched live on television on NBCSN and kicks off at 13:30 ET.
Best Opta match facts
Liverpool have won nine of their 10 top-flight home games against Watford, losing only in August 1999 on what was the Hornets’ first visit in the Premier League (0-1).
There has never been a goalless draw between these sides in the top-flight, with the 21 previous meetings producing a total of 72 goals (3.4 per game).
Liverpool have never lost consecutive Premier League games under Jurgen Klopp, last doing so in September 2015 with Brendan Rodgers in charge.
The Hornets have lost 16 of their 17 Premier League away games against sides starting that day in the top four of the table, winning only against Arsenal in January 2017.
Mohamed Salah has been directly involved in 47.1% of Liverpool’s 68 Premier League goals this season (24 goals, 8 assists) – the highest such ratio in the division this season.