Christophe Galtier's men have not beaten their opponents since Eden Hazard was on target in a 2-1 victory back in 2012, losing 11 and drawing three of the subsequent 14 encounters.
Having lost three and won one of their previous four fixtures, they are 14/1 (15.00) outsiders with dabblebet to record a long-awaited victory here.
None of the guests' last 21 matches have resulted in draws, but you can get odds of 13/2 (7.50) on them being forced to settle for a point on this occasion.
Thiago Maia, Adama Soumaoro and Kevin Malcuit are fighting to be fit after missing Les Dogues' 2-1 victory over Strasbourg, although Yassine Benzia did return to action from the bench.
Unai Emery will be without Thiago Motta due to injury and both Dani Alves and Kylian Mbappe through suspension.
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Shaky Parisian defence
Although unlikely to be too bothered by Mbappe's absence considering his other attacking options, Emery may feel slightly concerned by his side's defensive collapse in Brittany.
PSG endured an uncomfortable finish to the match at Roazhon Park after conceding twice in the final five minutes - the third time in four matches in which they have let in two goals in a game.
With just two clean sheets to their name in eight league games on the road, they may struggle to keep at bay a Lille team that has failed to score just once in their previous eight home games.
Tips and Predictions
Instead, odds of 5/4 (2.25) look like solid value on both teams finding the net for the fifth time in six encounters.