William Hill make Maurizio Sarri just 11/8 (2.38) to be the next Premier League manager to leave their position after a turbulent round of results.
The result was also the Blues' biggest defeat in the Premier League era. According to Opta, you have to go back to a 7-0 defeat against Nottingham Forest in April 1991 for the last time the Londoners were beaten by such an emphatic scoreline.
Sarri apologised for Chelsea's display at the Etihad Stadium, which saw them 4-0 down inside half an hour but it's now three defeats in their last four top-flight outings. Since the turn of the year, the club have won just two of six Premier League games, including a 4-0 loss to Bournemouth two weeks ago.
In terms of the sack race, the Italian was as big as 14/1 (15.0) in places before Sunday's defeat despite several stuttering displays. Now though, the 60-year-old leads the market having admitted that his job "is always at risk" in the post-match press conference but said any questions regarding his immediate future were to be directed at the club.
Having slipped to sixth in the Premier League table, it's understandable to see questions asked about Sarri's future, despite only a few months in charge.
Roman Abramovich has rarely shown patience with managers who fail to perform, even in the short term although Sarri's comments suggested that a lack of contact with the club's owner is not unusual.
"If the president calls, I'll be happy, seeing as I never hear from him. To be honest, I don't know what to expect," Sarri told Sky Italia following the latest defeat.
Should he remain at Stamford Bridge, there's the opportunity for Sarri to secure his first piece of silverware in English football as Chelsea face Manchester City in the Carabao Cup final later this month. The Blues are 2/1 (3.0) underdogs to lift the trophy at Wembley with table-topping City available at 4/11 (1.36) with William Hill.
Chelsea are now 5/4 (2.25) to finish in the top four but even if they fail to achieve that milestone, the Europa League could offer a viable alternative route to the Champions League next term. William Hill make the London club 4/1 (5.0) favourites to win the competition ahead of the round of 32 clash with Malmo on Thursday.
Elsewhere in the sack race market, Marco Silva is an 11/4 (3.75) chance to leave next.
Regular favourite Claude Puel is 7/2 (4.50) with plenty of questions over the future of Leicester City's under-fire boss, but the Frenchman has drifted off the back of results elsewhere over the weekend. Beyond that, it's 9/1 (10.0) that no Premier League boss leaves before the end of the season.