The first match of the inaugural edition of the Leagues Cup sees LA Galaxy face Tijuana at Dignity Health Sports Park in the early hours of Wednesday.
This new competition sees four sides from MLS face four of the top teams from Mexico's Liga MX. The last time these two teams met was in the quarter-finals of the CONCACAF Champions League in 2014, with Los Xolos triumphing 4-3 on aggregate.
The Galaxy currently sit second in MLS' Western Conference and come into the game off the back of a big win in their local derby with LAFC.
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Zlatan Ibrahimovic scored a stunning hat-trick in the El Trafico win over LAFC, yet with an MLS trip to Portland at the weekend it remains to be seen whether Barros starts the 37-year-old on Wednesday.
New signings Washington Camacho and Angel Sepulveda both scored on their debut in the Liga MX win over Puebla at the weekend and are pushing for a starting berth for Tijuana.
The Galaxy may sit second in the 12-team Western Conference, but only one side has scored fewer than their total of 30 goals.
Their home form has also been erratic, with the five-time MLS Cup winners losing four of their last six matches in front of their own fans and kept just two clean sheets in their last 13 league clashes there.
There is good reason to think that a Tijuana side - who got off to winning start in the Liga MX at the weekend - can score in Los Angeles and potentially cause their opponents some problems.
Tips and predictions
The price of 5/6 (1.83) for Tijuana in the Draw No Bet market should appeal, with our initial stake being returned if the match finishes level after 90 minutes.
Odds correct at the time of writing. Please gamble responsibly.