Lorenzo Gordinho returns to the Chiefs starting line-up, replacing Daniel Cardoso, who scored in Amakhosi's previous game.
Edmore Chirambadare also starts ahead of George Lebese in the Chiefs left wing, while Siphiwe Tshabalala will make his 29th appearance in the Soweto Derby which is a record.
New Pirates head coach Kljell Jonevret has named his starting line-up for his first Soweto Derby - with Thamsanqa Gabuza starting ahead of Tendai Ndoro upfront.
Patrick Phungwayo retains his place in the Bucs starting line-up with Thabo Matlaba out nursing an ankle injury.
Chiefs: Khune, Mphahlele, Gordinho, Mathoho, Masilela, Katsande, Molangoane, Maluleka, Chirambadare, Tshabalala, Parker.
Pirates: Mhlongo, Gcaba, Jele, Nyauza, Phungwayo, Manyisa, Mobara, Makola, Lorch, Wome, Gabuza.