Two weeks ago Manchester United were comfortably outplayed at Old Trafford by Juventus, with the Italian champions enjoying more possession, more shots, more corners, a better pass completion rate and more aerial duels won.
Crucially, Max Allegri's men also scored the only goal of the game and they will be confident of recording another victory at the Allianz Stadium where they boast a formidable record.
Real Madrid are the only side to have won a Champions League game away to Juventus in the last five years and bet365 offer the Italians at 6/10 (1.60).
United could be missing some key players for the trip to Turin, with Antonio Valencia sidelined and the out-of-form Romelu Lukaku a doubt. Marouane Fellaini is also a doubt having missed recent games with a groin injury.
Juve, for their part, have injury doubts over forwards Douglas Costa and Mario Mandzukic.
It was all too easy for Juve in Manchester two weeks ago, and despite winning their subsequent two league matches, we have seen little from United to make us think they will be able to avoid another defeat.
Cristiano Ronaldo faces his former club once more and he will be eager to make an impression, particularly in the competition where he has finished as top goal scorer in the last six seasons.
If Juve are likely to have the upper hand then Ronaldo should be involved and bet365 have some interesting markets involving the Portuguese forward.
Tips and predictions
Two weeks ago at Old Trafford, Ronaldo managed two shots on target and had one effort blocked, although he did not manage to get on the scoresheet.
bet365 offer him at 10/11 (1.91) to have over 2.5 shots on target in the game and that looks like an intriguing option for the clash.
Domestically Ronaldo is averaging 2.9 shots a game, and the top goalscorer in the history of the Champions League will surely be looking to step things up in his favourite competition.
Prices correct at time of writing. Please gamble responsibly.