The Nerazzurri were beaten 3-2 in the Spanish capital three weeks ago and are currently bottom of the group with just two points, whilst Los Blancos have only two points more than their opponents and are a place above them in the group.
Inter Milan vs Real Madrid Latest Odds
Inter Milan vs Real Madrid Team News
Antonio Conte will be unable to call upon the services of Daniele Padelli, Marcelo Brozovic and Aleksandar Kolarov who are all out due to coronavirus, while midfielders Matias Vecino and Stefano Sensi continue to be side-lined.
The visitors are without captain Sergio Ramos, while Brazilian duo Casemiro and Eder Militao are doubts having returned inconclusive coronavirus test results. Karim Benzema is a doubt.
Inter Milan vs Real Madrid Preview
These two teams finished with the best defensive records in their respective domestic divisions last season, yet this term both have struggled to recover that solidity.
Madrid have conceded in each of their last eight matches in all competitions, while Inter have kept just two clean sheets in 11 competitive fixtures.
The meeting on matchday three at the Estadio Alfredo di Stefano was an open and entertaining encounter and there is little reason to oppose a repeat on Wednesday.
Inter's forward duo of Romelu Lukaku and Lautaro Martinez are both in extremely strong form and will relish the prospect of facing a Madrid defence devoid of Ramos.
Going forward, Los Blancos have netted in 10 of their last 11 games and in 19 of their last 21 away Champions League matches, meaning they can generally be relied upon to contribute to high-scoring encounters.
Inter Milan vs Real Madrid Tips and Predictions
Both teams to score and over 2.5 goals is offered at 4/5 (1.80) and looks like an excellent selection. This bet has paid out in six of Real Madrid's last seven matches - as well in five of Inter's last eight - and has an strong chance of doing so once more this week.
Odds correct at the time of writing. Please gamble responsibly.