All 54 African national football association presidents were invited for the meeting which starts at noon in Johannesburg on Tuesday.
The main subject on the table is how Fifa will expand the World Cup from 32 to 48 teams. Here it is believed Africa's automatic spots will increase from five nations to nine, and the exact figure will be discussed during the meeting.
Then on Thursday Infantino will fly to Zimbabwe for football chief Philip Chiyangwa's birthday party.
Chiyangwa is the head of Southern African football's body, Cosafa. Confederation of African Football (Caf) president Issa Hayatou fears that the real purpose of Infantino's visit in Zimbabwe is to discuss support for a possible new Caf president, in Ahmad Ahmad, a former Malagasy government minister.
On March 16 Ahmad and Hayatou will go head to head to determine if the latter will continue in the post that he has held for 29 years in Africa.
Infantino will remember that Caf supported Bahrain's Sheikh Salman bin Ebrahim al Khalifa instead of him in last year's Fifa elections.
Meanwhile the South African Football Players Union (Safpu) is hoping to crash Fifa's party in South Africa. They have released the following statement to protest PSL club, Golden Arrows alleged poor treatment of Clifton Miheso:
Picketing At Fifa Summit
1. Safpu will be picketing: Time – 07H30
Date – 21 February 2017
Place – Sandton Convention Centre
2. This is after our genuine calls to the authority of football to investigate the incident at Golden Arrows where Clifton Miheso was allegedly forced to sign termination of contract at gun point, were never taken serious.
3. Amongst other things we will be DEMANDING the following:
(b) #RESPECT4CONTRACTUAL STABILITY
(c) #FOOTBALLERS RIGHTS TO CHOOSE
4. Possible handover of letter of demand to the Fifa President
5. Members of the community can join us as we seek justice and better treatment for our players, ENOUGH IS ENOUGH.