Liverpool have the chance to reclaim top spot in the Premier League when they welcome struggling United to Anfield on Sunday – Henderson and his team-mates 16 points clear of the sixth-placed Red Devils.
Liverpool have not won a league title since 1990, though the Reds came agonisingly close in 2014 when they were top of the table in April but Steven Gerrard's infamous slip and a 2-0 defeat at home to Chelsea proved their downfall.
Liverpool's capitulation has not been forgotten by Henderson, who said via The Telegraph: "That is something I have had to live with.
"But we are years on here, a totally different squad of players and totally different scenario.
"I don't like to look too far back into the past. All I'm focused on is to keep winning games for this football club, as many as we can, to be successful and to end up winning trophies."
"I feel we're ready," Henderson continued. "We definitely have the potential to win trophies.
"I have every confidence with the talent that we've got and the people in the dressing room that we can go and produce trophies in the very near future and hopefully it’s this season."
Liverpool have not beaten United in the Premier League since 2014, though Jurgen Klopp's men are overwhelming favourites to end that drought with Jose Mourinho's side managing just one victory from their last five league fixtures.
"It's extra special. Liverpool v United is a big game all over the world," Henderson added. "They're a world-class team with a world-class manager.
"They've got some world-class players and I'm not even sure when we last beat United in the league…Probably when you look at the table, you are a little bit surprised that they are not doing as well as they can be. But that doesn't mean they are less of a threat."