The Gunners are joined by Qarabag and Vorskla in Group E, with Maurizio Sarri’s troops welcoming Belarusian title holders BATE and Hungarian side Vidi to Group L.
That draw has handed the English top-flight heavyweights some lengthy trips out on the road, which could impact on their domestic efforts.
Elsewhere, Scottish champions Celtic have been paired with Salzburg, with Red Bull partners Leipzig and Norwegian outfit Rosenborg – a side the Hoops have already beaten in Champions League qualifying this season - joining them in Group B.
Europa League 2018-19 groups
|Group A||Group B||Group C||Group D|
|Bayer Leverkusen||Red Bull Salzburg||Zenit||Anderlecht|
|FC Zurich||RB Leipzig||Bordeaux||Dinamo Zagreb|
|AEK Larnaca||Rosenborg||Slavia Prague||Spartak Trnava|
|Group E||Group F||Group G||Group H|
|Sporting||AC Milan||Rapid Vienna||Marseille|
|Qarabag||Real Betis||Spartak Moscow||Eintracht Frankfurt|
|Group I||Group J||Group K||Group L|
Zenit are a side with plenty of elite experience in Europe and will face Bordeaux as part of their Group C campaign, Anderlecht must try to overcome Fenerbahce and Dinamo Zagreb in Group D, while Sevilla have been place in Group J with Krasnodar and Standard Liege.
Bayer Leverkusen will see Ludogorets as their biggest challengers in Group A, with Besiktas facing some big fixtures against Genk and Malmo in Group I.