Having won both of their opening matches, scoring eight goals and conceding two, the teams go into this clash separated only by their respective disciplinary records.
Currently top thanks to one fewer yellow card, Gareth Southgate's men are available at 8/5 (2.60) with dabblebet to make sure of first place by coming out on top here.
The Red Devils' only previous win over this opposition came way back in 1936, but there are odds of 2/1 (3.00) on offer on them making it two victories in 22 encounters.
An extra-time David Platt goal was the difference between the two teams when they met at the 1990 World Cup, and you can get odds of 21/10 (3.10) on them remaining all square after 90 minutes once again.
The Three Lions are expected to make changes, with Dele Alli once again set to sit out due to his minor thigh injury and Kyle Walker and Ruben Loftus-Cheek unlikely to start as they are one booking away from a suspension.
Roberto Martinez is also set to rotate his squad, meaning Romelu Lukaku, Dries Mertens and Eden Hazard will not be risked as they struggle with minor fitness problems.
With Group H still extremely open and therefore potential last 16 opponents difficult to predict, it is unlikely that this match will be played out in a particularly cagey or tactical manner.
Instead, another exciting game looks assured between two of the three joint top scorers in the tournament after two fixtures, with odds of 21/20 (2.05) well worth backing on over 2.5 goals being scored.
That bet would have paid out in both of England's two group games so far, as well as 12 of Belgium's last 15 fixtures in all competitions.