The likes of Thomas Lemar and Ousmane Dembele have been given nod, with Kylian Mbappe, who scored the winner against Peru in their last game, and Paul Pogba rested.
The French, who have already secured their progression to the last 16, have also changed goalkeepers and handed a start to Steve Mandanda, replacing Tottenham's Hugo Lloris.
Raphael Varane captains the side in Lloris's absence, with young PSG defender Presnel Kimpembe selected at centre-back alongside the Real Madrid man.
For Denmark, meanwhile, Martin Braithwaite and Andreas Cornelius are both brought into the starting XI having been named on the bench for the 1-1 draw with Australia.
The Danes need just a single point to join France in qualifying for the last 16 stage and will undoutedly again look to Tottenham midfielder Christian Eriksen for inspiration after his stunning goal in the last round of fixtures.
Denmark starting XI: Schmeichel, Kjaer, Christensen, Jorgensen, Dalsgaard, Stryger, Delaney, Eriksen, Braithwaite, Cornelius, Sisto.
France starting XI: Mandanda, Sidibe, Varane, Kimpembe, Hernandez, Kante, N'Zonzi, Dembele, Griezmann, Lemar, Giroud.